Examine This Report on Thai Betting Portals
Examine This Report on Thai Betting Portals
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). During the free ChVLig-AMP, the OB domain is mirrored from the NTase area to totally expose the DNA-binding floor previously mentioned the AMP-binding pocket. The peptide phase that's destined to be the latch is disordered inside the free ligase and sensitive to proteolysis, but this phase is protected from proteolysis when ChVLig binds to nicked DNA.
Pues bien, a la par de esta noticia hay otra buena que tiene que ver ya más con el tema de los abonos y las boletas para este semestre.
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An engineered phase three arrest mutant of DNA ligase would, if widely Lively, pepper the genome with unresected five′-adenylates at sites of DNA restore or joining of Okazaki fragments. This would be catastrophic if the level of DNA 5′-adenylylation exceeds the cell's capability to remove the lesions (33). This kind of scenario is analogous to “poisoning” of topoisomerase IB by camptothecin medicines or drug-mimetic enzyme mutations that selectively impede the DNA ligation stage of the topoisomerase pathway.
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